Transplantation · 1991 · 19 citations · 0 references
Life SciencesCell BiologyImmunologyCellular ImmunologyKidney TransplantationTransplant ImmunologyCell-mediated ImmunityCytotoxic T Lymphocyte ResponsesGraft RejectionHistocompatibilityTransplant RejectionGraft Rejection ImmunobiologyImmunologic Response To AllograftInterferon Gamma ProductionMhc Class Ii MoleculesRenal Transplant RejectionT Cell - Mediated RejectionT Cell-mediated Graft RejectionT-cell Mediated Rejection
Seventy-seven T cell clones were generated from cell blasts infiltrating rejected kidney allografts. All clones, either CD4 or CD8, displayed cytolytic activity evaluated by lectin-dependent cell-mediated cytotoxicity (LDCC) and natural killer activities. Furthermore, both types of clones were able to produce IFN-gamma following PHA stimulation. These data suggest that the graft infiltrate is characterized by T cell clones with cytolytic potential responsible for the killing of graft cells. The production of IFN-gamma, enhancing the class II MHC expression, may amplify the recipient immune response.