The renoprotective effects of berberine<i>via</i>the EP4-Gαs-cAMP signaling pathway in different stages of diabetes in rats

Abstract

These studies demonstrate, for the first time, that BBR exerts renoprotective effects in different stages of DN via EP4- Gαs- AC-cAMP signaling pathway in STZ-induced DN rats fed a high-sugar and high-fat diet.