ONE-POT STEREOSELECTIVE SYNTHESIS OF DIMETHY (2-HYDROXY-4,4-DIMETHYLCYCLOHEX-1-EN-6-ONE-1-YL)-3-(DIPHENYLPHOSPHONATO)BUTANEDIOATE

Abstract

Abstract Protonation of the reactive intermediate produced in the reaction between triphenyl phosphite and dimethyl acetylenedicarboxylate by 5,5-dimethylcyclohexane-1,3-dione leads to vinyltriphenoxyphosphonium cation, which undergoes an addition reaction with the enolate anion of the CH-acid to produce the title compound in high yield. Key Words: Phosphonato esterTriphenyl phosphiteAcetylenic ester: CH-acidNMR spectroscopyStereochemistry