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The correlation between molecular weight and antitumor activity of galactosaminoglycan (CO-N) from Cordyceps ophioglossoides.
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1989
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Protein-bound Polysaccharide Sn-cMedicinal ChemistryBioorganic ChemistryAntitumor ActivityBiochemistryOriginal Co-nNatural SciencesMedicineGlycobiologyCordyceps OphioglossoidesPolysaccharideTumor TargetingAnti-cancer AgentMolecular WeightPharmacologyCarbohydrate-protein InteractionDrug DiscoveryGlycosylation
A galactosaminoglycan (CO-N) obtained by ultrasonication from a protein-bound polysaccharide SN-C, which was isolated from Cordyceps ophioglossoides culture, has a direct cytotoxicity against tumor cells (Ohmori et al., Chem. Pharm. Bull., 37, 1019 (1989). High performance liquid chromatographic analysis revealed that CO-N shows a broad molecular weight distribution with an average molecular weight of 33000. A potent antitumor activity of CO-N was observed in the higher-molecular-weight fraction on gel filtration, and the low-molecular-weight fraction below 6600 showed a weak activity. However, the depolymerized CO-N (ca. 5500) obtained by further ultrasonication of the original CO-N still retained the antitumor activity of CO-N against Ehrlich ascitic carcinoma or MM46 solid mammary carcinoma.