Synlett · 2001 · 156 citations · 0 references
Natural SciencesChemical EngineeringChemistryCatalysisAddition ReactionsChiral RecognitionChiral SeparationCoordination ChemistryMetal-ligand BondingAmine BasesChiral Catalyst DesignEnantioselective CatalysisEnantioselective Catalyst DesignEnantioselective SynthesisPhosphoramidite ChemistryTransition-metal-catalyzed Functionalization
Phosphoramidite ligands, based on a chiral amine and atropoisomerically flexible biphenols, induce high enantioselectivities (ee's up to 98%) in the copper-catalyzed conjugate addition of dialkyl zinc reagents to a variety of Michael acceptors.