Interleukin 1 and tumour necrosis factor alpha may be responsible for the lytic mechanism during anti-tumour antibody-dependent cell-mediated cytotoxicity

An endotoxin-induced serum factor that causes necrosis of tumors.

E A Carswell, Lloyd J. Old, Robert Kassel et al. · Proceedings of the National Academy of Sciences · 1975 · 4.5K citations · Full text

Veterinary Medicine, Immunology, Pathobiology +15

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

M Kriegler, Carl F. Perez, Kim DeFay et al. · Cell · 1988 · 1.1K citations

Life Sciences, Immunology, Molecular Biology +11

Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.

Seijiro Okusawa, Jeffrey A. Gelfand, Takashi Ikejima et al. · Journal of Clinical Investigation · 1988 · 988 citations · Full text

Medicine, Immunology, Pharmacology +17

Human interleukin 1 is a cytocidal factor for several tumor cell lines.

Kikuo Onozaki, Koji Matsushima, B B Aggarwal et al. · The Journal of Immunology · 1985 · 377 citations

Life Sciences, Cell Biology, Immunology +9

Macrophages and metastasis--a biological approach to cancer therapy.

Isaiah J. Fidler · PubMed · 1985 · 346 citations

Medicine, Cancer Biology, Oncology +14