Journal of the American Medical Association · 1950 · 67 citations · 8 references
MedicineEndocrinologyOncologyEndocrine OncologyProstate DiseaseSteroid BiochemistryAdrenal HormonesAdrenal Steroid HormonesHormonal Cancer TherapyHormonal TherapyPituitary Gland FunctionSteroid PharmacologyAdrenal Cortex FunctionAdrenal Cortical Hormones
It is now well established that androgenic and estrogenic steroids produce temporary regression of malignant tissue of the breast<sup>1</sup>in certain cases and that estrogenic steroids also have an anticarcinogenic effect on prostatic cancer.<sup>2</sup>There is also some evidence that progesterone may have a similar effect on carcinoma of the cervix,<sup>3</sup>breast<sup>4</sup>and prostate.<sup>5</sup>When pituitary adrenocorticotropic hormone (ACTH) and cortisone became available for clinical trial, it seemed logical to attempt to evaluate their effect on various types of malignant lesions. Murphy and Sturm<sup>6</sup>reported favorable results on transplanted leukemia in rats with pituitary adrenocorticotropic hormone or adrenal cortical extract. Heilman and Kendall<sup>7</sup>produced an arrest of the growth of malignant lymphoid tumor in the mouse with the administration of cortisone. Pearson and others<sup>8</sup>have reported temporary remission in Hodgkin's disease, acute leukemia and chronic lymphatic leukemia in man after use of
8
Charles Huggins · Archives of surgery · 1941 · 1.5K citations
Charles Huggins, William W. Scott, Clarence V. Hodges · The Journal of Urology · 1941 · 153 citations
Medicine, Endocrinology, Urology +9