Concepedia

Thermodynamic Analysis of Structure-Activity Relationships of Drugs: Prediction of Optimal Structure

Takeru Higuchi, Stanley S. Davis

Journal of Pharmaceutical Sciences · 1970 · 78 citations · 18 references

DOI

Concepts

References

18

<i>p</i>-σ-π Analysis. A Method for the Correlation of Biological Activity and Chemical Structure

Corwin Hansch, Toshio Fujita · Journal of the American Chemical Society · 1964 · 2.3K citations

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A Mathematical Contribution to Structure-Activity Studies

Spencer M. Free, James W. Wilson · Journal of Medicinal Chemistry · 1964 · 951 citations

, , +7

The use of chemical potentials as indices of toxicity

John Ferguson · Proceedings of the Royal Society of London. Series B, Biological sciences · 1939 · 556 citations

, , +14

Parabolic dependence of drug action upon lipophilic character as revealed by a study of hypnotics

Corwin Hansch, Annette Steward, Susan M. Anderson et al. · Journal of Medicinal Chemistry · 1968 · 233 citations

, , +9

Thermodynamic analysis of the relative effectiveness of narcotics

Frank Brink, J Posternak · Journal of Cellular and Comparative Physiology · 1948 · 132 citations

, , +7