Phenelzine and Dexamphetamine in Depressive Illness

Abstract

affective disorders. We have found, for instance, that those patients with anxiety states or depressions most likely to respond to M.A.O.I., or to M.A.O.I. combined with chlordiazepoxide, do generally have certain characteristics in common. Early-morning waking may be present, but more often there is an inability to get to sleep, or there may even be an increased depth of sleep. Many patients also tend to get worse as the day goes on rather than better, which is very different from the constant early-morning waking and diurnal mood- swing of the true endogenous depression. Severe fatigue is a common complaint, and there is a great variation in the patient's symptoms and in his emotionality from day to day. Patients also tend to blame others rather than themselves, and premenstrual tension and irritability are very commonly found in the symptomatology of women who are going to make a good response to the M.A.O.I. drugs.