Publication | Closed Access
Direct trifluoromethylthiolation of aryl halides using methyl fluorosulfonyldifluoroacetate and sulfur
87
Citations
6
References
1993
Year
Chemical EngineeringDirect TrifluoromethylthiolationDerivativesEngineeringDerivative (Chemistry)Derivatives 3Fluorous SynthesisOrganic ChemistryChemistryHalogenationChemical DerivativeBiomolecular EngineeringMethyl Fluorosulfonyldifluoroacetate 1Good Yields
In the presence of S8 and copper(I) iodide, methyl fluorosulfonyldifluoroacetate 1 reacts with aryl halides 2 in hexamethylphosphoramide (HMPA) or N-methylpyrrolidinone (NMP) at 100–110 °C to give the corresponding trifluoromethylthiolated derivatives 3 in good yields.
| Year | Citations | |
|---|---|---|
Page 1
Page 1