Synthesis and Evaluation of Influenza Virus Sialidase Inhibitory Activity of Hinokiflavone-Sialic Acid Conjugates

Abstract

- The known biflavonoid, hinokiflavone (1) was isolated from the leaves of Metasequoia glyptostroboides Hu et Cheng and displayed influenza A and B virus sialidase inhibitory activity. The unnatural glycoconjugate, hinokiflavone-sialic acid (8) was synthesized and exhibited more potent inhibitory activity.