Biosynthesis of <i>p</i>‐Hydroxylated Aromatics

Abstract

Abstract A bioconversion process with Aspergillus parasiticus has been developed to enhance p ‐hydroxylation activities with respect to aromatic substrates such as m ‐terphenyl. Through modified growth conditions, we are improving product concentration, while streamlining fermentation and downstream processing requirements. We routinely carry out biosynthetic conversions with m ‐terphenyl at the 300‐L scale and produce over 200 g of 4,4″‐dihydroxy‐ m ‐terphenyl at a concentration of 0.7 g/L in the fermentation vessel.