Pilot Randomized, Placebo Controlled Trial to Investigate the Effect of Antibiotic Prophylaxis on the Rate of Urinary Tract Infection in Infants with Prenatal Hydronephrosis

Abstract

Based on the results of our pilot study a realistic recruitment rate for this group of patients is established, making a definitive trial of this topic feasible. However, due to the low number of eligible patients multicenter collaboration is critical to address the effect of continuous antibiotic prophylaxis on the urinary tract infection rate in this population. After study enrollment high medication and followup compliance can be expected.