Resveratrol Oligomers from <i>Vatica albiramis</i>

Naohito Abe, Tetsuro Ito, Kenji Ohguchi, Minori Nasu, Yuichi Masuda, Masayoshi Oyama, Yoshinori Nozawa, Masafumi Ito, Munekazu Iinuma

Journal of Natural Products · 2010 · 53 citations · 30 references

Concepts

Abstract

Five new stilbenoids, vatalbinosides A-E (1-5), and 13 known compounds (6-18) were isolated from the stem of Vatica albiramis. The effects of these new compounds on interleukin-1β-induced production of matrix metalloproteinase-1 (MMP-1) in human dermal fibroblasts were examined. Three resveratrol tetramers, (-)-hopeaphenol (6), vaticanol C (13), and stenophyllol C (14), were identified as strong inhibitors of MMP-1 production.

References

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