Selective Effect of Mercury on Th2-Type Cytokine Production in Humans

Abstract

IL-4 production significantly increased at low concentrations of CH(3)Hg (0.5 uM, p < 0.01), while gamma-IFN production was suppressed starting at CH(3)Hg 2 uM (p = 0.004). Inorganic mercury (HgCl(2)) increased IL-4 only at concentrations 10-20 times higher than CH(3)Hg. These findings suggest a mechanism by which mercury could trigger or potentiate TH2 cytokine production in humans.