Proceedings of the National Academy of Sciences · 2002 · 312 citations · 22 references
Inhibitor Alpha-amanitinTranscriptional RegulationSystems BiologyEngineeringRna Polymerase IiTranscription RegulationRna Structure PredictionRna BiologyMolecular BiologyDna ReplicationStructural BasisTranscription MechanismGene TranscriptionGene ExpressionMedicineStructural BiologyBiomolecular Engineering
The structure of RNA polymerase II in a complex with the inhibitor alpha-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism.
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