Chronic Angiotensin II Receptor Blockade Induces Cardioprotection During Ischemia by Increased PKC-ε Expression in the Mouse Heart

Abstract

Chronic AT1-receptor antagonism is capable of protecting the heart against myocardial infarction in a PKC-epsilon-dependent way. Furthermore, chronic treatment with ACE-I is suggested to have suppressing effects on iPC, possibly caused by reduced PKC-epsilon expression.