Importance of Multi-lineage Hematologic Involvement and Hypoalbuminemia at Diagnosis in Patients With “Risk-organ” Multi-system Langerhans Cell Histiocytosis

Abstract

Anemia with thrombocytopenia with or without leukopenia and hypoalbuminemia, were associated with worse prognosis in multi-system Langerhans cell histiocytosis. Other therapeutic strategies should be considered at diagnosis or early during the initial treatment for this high risk subgroup of patients.