Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing

Bioconductor: open software development for computational biology and bioinformatics

Robert Gentleman, Vincent J. Carey, Douglas M. Bates et al. · Genome biology · 2004 · 12.5K citations · Full text

Life Sciences, Bioinformatics, Computational Biology +8

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

Gordon K. Smyth · Statistical Applications in Genetics and Molecular Biology · 2004 · 12K citations

Life Sciences, Biostatistics, Bayesian Biostatistics +13

A germline-specific class of small RNAs binds mammalian Piwi proteins

Angélique Girard, Ravi Sachidanandam, Gregory J. Hannon et al. · Nature · 2006 · 1.8K citations

Life Sciences, Molecular Biology, Molecular Genetics +11

A<i>cre</i>-transgenic mouse strain for the ubiquitous deletion of<i>loxP</i>-flanked gene segments including deletion in germ cells

Frieder Schwenk, Udo Baron, Klaus Rajewsky · Nucleic Acids Research · 1995 · 1.3K citations

Life Sciences, Genetics, Molecular Genetics +15

A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice

Alexei A. Aravin, Ravi Sachidanandam, Déborah Bourc’his et al. · Molecular Cell · 2008 · 1.2K citations · Full text

Medicine, Genetics, Molecular Genetics +14