Concepedia

Leflunomide Treatment of Crohn's Disease Patients Intolerant to Standard Immunomodulator Therapy

Devang Prajapati, Joshua F. Knox, Jeanne Emmons, Kia Saeian, Mary Ellen Csuka, David G. Binion

Journal of Clinical Gastroenterology · 2003 · 39 citations · 9 references

DOI

Abstract

Our case series demonstrates that the pyrimidine analog leflunomide may be effective for treating moderate to severe CD patients intolerant to standard immunomodulator therapy and warrants further investigation in a randomized controlled trial.

References

9

Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial

Stephen B. Hanauer, Brian G. Feagan, Gary R. Lichtenstein et al. · The Lancet · 2002 · 4.1K citations

, , +5

Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial

Josef S Smolen, Joachim R. Kalden, David L. Scott et al. · The Lancet · 1999 · 769 citations

, , +8

A Comparison of Methotrexate with Placebo for the Maintenance of Remission in Crohn's Disease

Brian G. Feagan, Richard N. Fedorak, E. Jan Irvine et al. · New England Journal of Medicine · 2000 · 721 citations · Full text

The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review

Alan G. Fraser · Gut · 2002 · 626 citations · Full text

A controlled double blind study of azathioprine in the management of Crohn's disease.

Sally Candy, John Wright, Michele Gerber et al. · Gut · 1995 · 570 citations · Full text