Alfentanil infusions for peroperative and postoperative analgesia

Abstract

Abstract The theoretical and clinical data available to date on the use of alfentanil by infusion as a supplement to N 2 O anaesthesia are summarized. These data suggest that alfentanil plasma levels of 200–400 ng/ml are required to provide adequate peroperative analgesia, depending upon the severity of the surgical procedure. Patients may be expected to awaken and breathe spontaneously at plasma levels of less than 200 ng/ml. Infusion regimens that achieve the required plasma levels without prolonging recovery are recommended for both minor and major surgery. Tentative suggestions are also given for the use of alfentanil by infusion in the postoperative period in spontaneously breathing patients.