The presence of .ALPHA.-amino-.BETA..GAMMA.-dihydroxybutyric acid in hydrolysates of actinomycin Z1.

Abstract

Actinomycin Z1, synthesized by Streptomyces fradiae contains only one residue of the amino acid, threonine. Hydrolysates of actinomycin Z1 were investigated using paper, gas and ion-exchange chromatographic procedures. Identification of an unknown amino acid in actinomycin Z1 (and other actinomycins of the Z series) as α-amino-β, γ-dihydroxybutyric acid (hydroxythreonine) was confirmed by massspectrometry.