Tris(4-<i>t</i>-butylphenylcarbamate)s of Cellulose and Amylose as Useful Chiral Stationary Phases for Chromatographic Optical Resolution

Abstract

Abstract Cellulose tris(4-t-butylphenylcarbamate) and amylose tris(4-t-butylphenylcarbamate) were adsorbed on macroporous silica gel and used as chiral stationary phases for high-performance liquid chromatography to separate racemic compounds. The carbamates, particularly cellulose derivative, exhibited remarkable optical resolving power, and resolved racemic drugs such as chloroquine and nicardipine which were not resolved on other phenylcarbamate derivatives of cellulose and amylose.