Nickel-Catalyzed Highly Chemo-, Regio-, and Stereoselective Three-Component Reaction of Norbornene with Two Alkynes

Abstract

The first three-component reaction of norbornene with two alkynes leading to 1,5-enyne via C-H bond activation of terminal silylacetylene was achieved using a Ni(cod)(2)/phosphine catalyst. This reaction is applicable for various internal alkynes and norbornene derivatives with high regio- and stereoselectivities.