Anesthesia & Analgesia · 2004 · 36 citations · 18 references
NursingPharmacologyPharmacotherapyAnesthesiaCritical Care PharmacotherapyPain ManagementAdverse Effects Of AnalgesicsAnalgesiaGeneral Anesthetic AgentsOpioid AnalgesicsOpioid ManagementOpioid TherapyAnalgesia For BurnsAnalgesic Sparing EffectBurn TreatmentIntestinal IleusKetamine PharmacologyKetamine TherapyKetamine-based AnesthesiaPostoperative Abdominal Distension
We present a case in which ketamine was used for long-term sedation and analgesia of a burn patient. Under escalating opiate dosages, the patient had developed persistent ileus as well as abdominal distension that caused respiratory compromise, without receiving sufficient analgesia. The opiate-sparing effect of the continuous ketamine infusion was more than 90%. The ileus resolved within 24 h. The quality of sedation also changed favorably. There were no obvious adverse effects of ketamine.
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μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
Laura Bohn, Raul R. Gainetdinov, Fang‐Tsyr Lin et al. · Nature · 2000 · 916 citations
Medicine, Neuroscience, Pharmacology +14
Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization
He Li, Jamie Fong, Mark von Zastrow et al. · Cell · 2002 · 338 citations · Full text
Management of pain during debridement: a survey of U.S. burn units
Samuel W. Perry, George Heidrich · Pain · 1982 · 328 citations
Medicine, Pharmacotherapy, Surgery +17
John Hansen‐Flaschen, Shari A. Brazinsky, Christian Basile et al. · Survey of Anesthesiology · 1992 · 273 citations
Health Professions, Critical Care Nursing, Pharmacotherapy +16