Synthesis of 2-Cyclohexenone Derivatives via Gold(I)-Catalyzed Hydrative Cyclization of 1,6-Diynes

Abstract

The gold(I) complex (MeAuPPh3) was found to be a highly effective catalyst for the hydrative cyclization of 1,6-diynes to form the corresponding 3-methyl hex-2-enone derivatives with good to excellent yield. The proposed mechanism is described.