The inhibitory receptor <scp>CD</scp>300a is up‐regulated by hypoxia and <scp>GM</scp>‐<scp>CSF</scp> in human peripheral blood eosinophils

Abstract

CD300a expression is up-regulated by hypoxia, and GM-CSF where HIF-1 might play an important role. These results are important for the understanding of eosinophils behavior in inflamed tissue and suggest a new effect on their function in allergic inflammation. Taken together our data point out CD300a as a novel target for the treatment of allergy.