Glucose-6-phosphate dehydrogenase and catalase activities in erythrocytes of schizophrenic patients under pharmacotherapy with traditional antipsychotics

Abstract

We studied the activities of glucose-6-phosphate dehydrogenase and catalase in erythrocytes of schizophrenia patients who were under pharmacotherapy with traditional antipsychotic drugs. Prior to therapy, we observed decreased activity of glucose-6-phosphate dehydrogenase and increased activity of catalase in patients compared to the control. After a 6-week therapy with antipsychotics of the first generation, catalase activity became normal, whereas the activity of glucose-6-phosphate dehydrogenase declined further.