Long-term <scp>l</scp> -Arginine Supplementation Improves Small-Vessel Coronary Endothelial Function in Humans

Abstract

Long-term oral L-arginine supplementation for 6 months in humans improves coronary small-vessel endothelial function in association with a significant improvement in symptoms and a decrease in plasma endothelin concentrations. This study proposes a role for L-arginine as a therapeutic option for patients with coronary endothelial dysfunction and nonobstructive coronary artery disease.