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Chemoenzymatic synthesis2 of both enantiomers of fluoxetine, tomoxetine and nisoxetine: lipase-catalyzed resolution of 3-aryl-3-hydroxypropanenitriles

Medicinal ChemistryPharmaceutical ChemistryBiochemistryChemoenzymatic Synthesis2Natural SciencesMedicineStereoselective SynthesisPharmacologyLipase-catalyzed ResolutionEnantioselective SynthesisDrug DiscoveryNatural Product Synthesis