Potentiation of Lethality in Mice by Combinations of Pentazocine and Tripelennamine

Abstract

Quantal dose-response curves were generated to determine the median lethal doses (LD50S) for pentazocine and tripelennamine, either alone or in combination. LD50S of the drug combinations in mice demonstrated significant potentiation when compared with either drug administered alone. Attempts to antagonize the lethality of such combinations have, to date, been unsuccessful.