Changes in nitric oxide synthase isoforms in the spinal cord of rat following induction of chronic arthritis

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

Kenneth Hargreaves, Ronald Dubner, Frederick J. Brown et al. · Pain · 1988 · 5.2K citations

Medicine, Pharmacology, Behavioral Pharmacology +16

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

John Garthwaite, Sarah L. Charles, Russ Chess‐Williams · Nature · 1988 · 2.6K citations

Life Sciences, Neurobiology, Neuroscience +13

The effects of a non-competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation

Ke Ren, Janice L.K. Hylden, Gene M. Williams et al. · Pain · 1992 · 415 citations

Medicine, Neurobiology, Pharmacology +17

Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats

Annika B. Malmberg, Tony L. Yaksh · Pain · 1993 · 384 citations

Medicine, Neuroscience, Pharmacology +15

The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli

Jiřı́ Paleček, V. Palečková, LS Sorkin et al. · Journal of Neuroscience · 1992 · 366 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17