Acquired Factor IX Deficiency

Abstract

Coagulation studies in 2 patients revealed decreased factor IX activity. Family history of factor IX deficiency or bleeding disorder was not present and the past history of the patients did not disclose any evidence of congenital hemorrhagic disorder. They did not require any plasma or plasma product for the control of their bleeding diathesis and decreased factor IX activity returned to normal in a relatively short period of time. Factor IX deficiency was due to a circulating anticoagulant. With corticosteroid treatment, marked clinical improvement occurred in the second patient with some improvement of her coagulation studies, but it did not seem to effect the circulating anticoagulant level in the first patient