Concepedia

N‐Heterocyclic Carbene‐Catalyzed Reaction of Alkynyl Aldehydes with 1,3‐Keto Esters or 1,3‐Diketones

Advanced Synthesis & Catalysis · 2010 · 109 citations · 42 references

Concepts

Functionalized 3,4‐DihydropyranonesEngineeringN‐heterocyclic Carbene‐catalyzed ReactionHeterocyclicAtom‐economical AccessOrganic ChemistryCatalysisChemistryHeterocycle ChemistryAlkynyl Aldehydes

Abstract

Abstract The N‐heterocyclic carbene‐catalyzed reaction of alkynyl aldehydes with 1,3‐keto esters or 1,3‐diketones has been studied. This protocol offers an entirely new, mild and atom‐economical access to highly functionalized 3,4‐dihydropyranones.

References

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Advantage Organocatalysis, Novel Organocatalysts, Engineering +13

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