The effect of R-factor plasmids on host-cell responses to nalidixic acid I. Increased susceptibility of nalidixic acid-sensitive hosts

Abstract

Investigation of the antibacterial activity of nalidixic acid against Escherichia coli harbouring various R-factor plasmids has shown that several unrelated R-factors confer an increased susceptibility to the drug. This increase in susceptibility results from an increase in the permeability of the cell wall facilitating an increased uptake of the drug.