Novel non-peptidic and small-sized BACE1 inhibitors

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

Purification and cloning of amyloid precursor protein β-secretase from human brain

Sukanto Sinha, John P. Anderson, Robin Barbour et al. · Nature · 1999 · 1.6K citations

Neurodegenerative Diseases, Protein Secretion, Molecular Neuroscience +8

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

Riqiang Yan, Michael J. Bienkowski, Mary E. Shuck et al. · Nature · 1999 · 1.4K citations

Alzheimer's Disease, Biochemistry, Proteasome +3

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

Ishrut Hussain, David J. Powell, David Howlett et al. · Molecular and Cellular Neuroscience · 1999 · 1.1K citations

Proteomic Technology, Protein Secretion, Protein Function +7

Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor

Hong Lin, Gerald Koelsch, Xinli Lin et al. · Science · 2000 · 701 citations