Synthesis · 1984 · 100 citations · 0 references
Natural SciencesChemistryCatalysisOrganic ChemistryCatalyst PreparationCatalyst SynthesisHeterocycle SynthesisOrganic SynthesisAlkyne Coupling ReactionsAlkyne Cycloaddition ReactionsPalladium Catalysts
1,1-Dimethylpropargyl alc. was treated with RX (R = 2-thienyl 2-pyridyl, O2NC6H4; X = halo), R1X1 (R1 = Ph, 2-benzothienyl, 2-thienyl; X1 = halo), (Ph3P)4Pd, CuI, and PhCH2N+Et3 Cl- to yield RC≡CR1. The reaction of 2-iodothiophene with HC≡CCMe2OH, 2,5-dibromothiophene, (Ph3P)4Pd, CuI, PhCH2N+Et3 Cl-, and NaOH in C6H6 gave thiophene deriv. I.