Publication | Open Access
CP2289, a New 5-HT3 Receptor Ligand: Agonistic Activities on Gastroenteric Motility.
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1997
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Gastroenteric MotilityGastrointestinal PharmacologyGastroenterologyBezold-jarisch ReflexDigestive TractExperimental PharmacologyGastrointestinal Peptide HormoneMolecular PharmacologyFunctional Gastrointestinal DisorderGastric Emptying TestsCell SignalingG Protein-coupled ReceptorAgonistic ActivitiesExcised Ileal MuscleReceptor (Biochemistry)NeuropharmacologyPharmacologySignal TransductionPhysiologyMedicine
A new 5-HT3 receptor ligand, CP2289, was synthesized and pharmacologically tested. Although CP2289 inhibited the Bezold-Jarisch reflex, it contracted the excised ileal muscle of mice, rats and guinea pigs. This response may reflect a partial agonist character of CP2289 in the gut. In vivo antiemetic and gastric emptying tests gave similar results.