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Cerebral Proton Magnetic Resonance Spectroscopy in Rett Syndrome
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1995
Year
NeurophysiologyNeuroanatomyRett SyndromeMedicineNeurological DisorderMagnetic Resonance SpectroscopyCorticobasal DegenerationDegenerative DiseaseNeurologyNeuroscienceNeurodegenerationMri/mrs StudiesNeuropathologySecondary Degenerative ProcessBrain PathologySocial SciencesRadiology
Combined MRI/MRS studies were performed in 9 girls with Rett syndrome of different ages. NAA, as marker of neuronal tissue, was found to decrease with increasing age. There was no evidence for a defective energy metabolism. The data point towards a probably secondary degenerative process in the pathogenesis of Rett syndrome.