Trimethoprim-Sulfamethoxazole Compared with Vancomycin for the Treatment of <i>Staphylococcus aureus</i> Infection

Abstract

Vancomycin is superior to TMP-SMZ in efficacy and safety when treating intravenous drug users who have staphylococcal infections. However, all treatment failures occurred in patients with MSSA infection at any site. Therefore, TMP-SMZ may be considered as an alternative to vancomycin in selected cases of MRSA infection.