DIFFERENTIAL NF-??B AND I??B GENE EXPRESSION DURING DEVELOPMENT OF CARDIAC ALLOGRAFT REJECTION VERSUS CD154 MONOCLONAL ANTIBODY-INDUCED TOLERANCE1

Abstract

We conclude that, whereas blanket approaches to NF-kappaB suppression are unlikely to be effective strategies for tolerance induction, a better understanding of the roles of individual NF-kappaB and IkappaB genes may allow development of more precise and effective therapies.