Progesterone withdrawal I: pro-convulsant effects

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

Maria Dorota Majewska, Neil L. Harrison, Rochelle D. Schwartz et al. · Science · 1986 · 2.2K citations

Medicine, Neuroscience, Pharmacology +17

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.

R. H. Purdy, A. Leslie Morrow, Perry H. Moore et al. · Proceedings of the National Academy of Sciences · 1991 · 960 citations

Life Sciences, Neurobiology, Neuroscience +14

GABAA receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid

Sheryl S. Smith, Qi Hua Gong, Fu‐Chun Hsu et al. · Nature · 1998 · 568 citations

Life Sciences, Biochemistry, Pharmacology +12

Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor

Daniel Bitran, Robert J. Hilvers, Carol K. Kellogg · Brain Research · 1991 · 457 citations · Full text

Medicine, Neuroscience, Pharmacology +12

Withdrawal from 3α-OH-5α-Pregnan-20-One Using a Pseudopregnancy Model Alters the Kinetics of Hippocampal GABA_A-Gated Current and Increases the GABA_AReceptor α4 Subunit in Association with Increased Anxiety

Sheryl S. Smith, Qi Hua Gong, Xinshe Li et al. · Journal of Neuroscience · 1998 · 353 citations · Full text

Medicine, Neurobiology, Neuroscience +17