High Prevalence of <i>Streptococcus pneumoniae</i> with Mutations in <i>pbp1a</i>, <i>pbp2x</i>, and <i>pbp2b</i> Genes of Penicillin-Binding Proteins in the Nasopharynx in Children in Japan

Abstract

PCR-based genotyping can characterize the antimicrobial resistances in pneumococci along with minimal inhibitory concentrations (MICs). Physicians should pay attention to the recent increase in antimicrobial-resistant S. pneumoniae when treating pediatric acute otitis media.