MALE HORMONE SUBSTANCE: A PRIME FACTOR IN ACNE1

Abstract

ADMINISTRATION of male hormone substance has been observed to result in acneform eruptions in an eunuchoid man (1). In this instance the formation of acne was clearly and unmistakably associated with the androgenic therapy, a fact confirmed in another eunuchoid individual (2). The present report is an analysis in men, women and children of the relationship of androgens to experimentally induced and naturally occurring acne. Before presenta’ tion of these observations brief statement and evaluation are given of the nature of sebaceous secretions and of certain basic data about acne such as incidence and conceptions of etiology, pathogenesis and the influence of endocrine and other factors.