Alteration of Anesthetic Requirement by Amphetamine

Abstract

The effects of acute and chronic administration of dextroamphetamine (DA) on halothane MAC in dogs were evaluated. Acute intravenous administration of DA, 0.1, 0.5, and 1 mg/kg, during halo thane anesthesia was associated with increases of MAC to 19 ±8, 67 ± 11, and 96 ± 15 per cent above control va