A Systematic, Updated Review on the Antidepressant Agomelatine Focusing on its Melatonergic Modulation

Abstract

Although a bias in properly assessing the "sleep core" of depression may still exist with current screening instruments, therefore making difficult to compare agomelatine' efficacy to other antidepressant ones, comparative studies showed agomelatine to be an intriguing option for depression and, potentially, for other therapeutic targets as well.