Anesthesiology · 1974 · 50 citations · 0 references
MedicinePharmacokineticsToxicologyDrug MetabolismMetabolismFluoride MetabolismMetabolite IdentificationSpecies Differences In Drug MetabolismUrinary ExcretionFluoride ToxicologyIsoflurane AnesthesiaUrinary Fluoride Excretion
The metabolism of isoflurane was studied in Fischer 344 rats and man. In both species, ionic fluoride and non-ionic fluoride were detected in urine, with ionic fluoride the principal metabolite in rats and non-ionic fluoride the predominant end-product in man. Thin-layer chromatography indicated tha