EngineeringBioengineeringBiological EngineeringBiochemical EngineeringNetwork BiologyBiological NetworksCircuit MotifsBiochemical Reaction NetworksCircuit RobustnessDesign PrinciplesEvolution Of Biological NetworksEvolutionary TinkeringGene Circuit DesignGene Circuit Evolution
This viewpoint comments on recent advances in understanding the design principles of biological networks. It highlights the surprising discovery of "good-engineering" principles in biochemical circuitry that evolved by random tinkering.
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Network Motifs: Simple Building Blocks of Complex Networks
Ron Milo, Shai S. Shen-Orr, Shalev Itzkovitz et al. · Science · 2002 · 7.5K citations
Hierarchical Organization of Modularity in Metabolic Networks
A. L. Somera, D. A. Mongru, Zoltán N. Oltvai et al. · Science · 2002 · 4.3K citations · Full text
From molecular to modular cell biology
Leland H. Hartwell, J. J. Hopfield, Stanislas Leibler et al. · Nature · 1999 · 3.7K citations