GRAFT-VERSUS-LEUKEMIA EFFECT IN MINOR ANTIGEN MISMATCHED CHIMERAS GIVEN DELAYED DONOR LEUCOCYTE INFUSION: IMMUNOREGULATORY ASPECTS AND ROLE OF DONOR T AND ASGM1-POSITIVE CELLS1

Abstract

In minor antigen mismatched BM chimeras, anti-host reactivity after DLI is characterized by (1) an absence of clinical GVHD, (2) clonal deletion of host-reactive CD8 cells, (3) an absence of anti-host CTL induction, and ( 4) a temporary persistence of host-reactive CD4 T cells and of MLR reactivity. In addition, either donor ASGM1+ cells or an interaction between these cells and T cells contribute to the GVL effect.