Asymmetric Synthesis of <i>syn</i>-α-Substituted β-Amino Ketones by Using Sulfinimines and Prochiral Weinreb Amide Enolates

Abstract

Syn-alpha-substituted beta-amino Weinreb amides are new chiral building blocks for asymmetric synthesis of syn-alpha-substituted beta-amino acids, aldehydes, and ketones and are prepared by addition of prochiral lithium enolates of Weinreb amides to sulfinimines (N-sulfinyl imines).